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Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease

7 Dec 2021

Abstract excerpt

Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However, technical challenges in in-vivo assessments have impeded research into the role of the LC in Alzheimer's disease. We studied participants with or known to be at-risk for mutations in genes causing autosomal-dominant Alzheimer's...

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PMID: 35045380
DOI: 10.1016/j.neurobiolaging.2021.11.006

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