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Article

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.

PloS one - 1 Jan 2016

Rundberg Nilsson Alexandra, Soneji Shamit, Adolfsson Sofia, Bryder David, Pronk Cornelis Jan

Abstract excerpt

Aging within the human hematopoietic system associates with various deficiencies and disease states, including anemia, myeloid neoplasms and reduced adaptive immune responses. Similar phenotypes are observed in mice and have been linked to alterations arising at the hematopoietic stem cell (HSC)...

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Identifiers

PMID: 27368054
DOI: 10.1371/journal.pone.0158369
PMCID: PMC4930192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-27368054-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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