Article

CD61 identifies a superior population of aged murine hematopoietic stem cells and is required to preserve quiescence and self-renewal

2023-08-14

Abstract excerpt

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged HSCs. Here we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain sel...

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Literature Corpus work: 9afeac7c-599d-5388-8def-b30976b357af
DOI: 10.1101/2023.08.14.553203

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