Article
Polymorphisms in Toll-Like receptors genes and their associations with immunological parameters in Plasmodium vivax malaria in the Brazil-French Guiana Border.
Cytokine - 1 Sept 2023
Ramírez Aina D R, de Jesus Myrela C S, Menezes Rubens A O, Santos-Filho Marcelo C, Gomes Margarete S M, Pimenta Tamirys S, Barbosa Vanessa S, Rossit Julia, Reis Nathalia F, Brito Simone Cristina Pereira, Sampaio Marrara Pereira, Cassiano Gustavo C, Storti-Melo Luciane M, Baptista Andrea R S, Machado Ricardo L D
Abstract excerpt
BACKGROUND: The innate immune response plays an important role during malaria. Toll-like receptors (TLR) are capable of recognizing pathogen molecules. We aimed to evaluate five polymorphisms in TLR-4, TLR-6, and TLR-9 genes and their association with cytokine levels and clinical parameters in malaria from the Brazil-French Guiana border. METHODS: A case-control study was conducted in Amapá, Brazil. P. vivax...
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