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Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit Their Clinical Utility.

Biological psychiatry - 15 Sept 2025

Mollon Josephine, Schultz Laura M, Knowles Emma E M, Jacquemont Sebastien, Glahn David C, Almasy Laura

Abstract excerpt

BACKGROUND: There has been little examination of the stability and validity of polygenic risk scores (PRSs), i.e., whether individuals identified as high risk for a disorder with one PRS are identified as high risk with another PRS and whether high-risk individuals have the disorder. METHODS: The UK Biobank recruited 502,534 individuals ages 37 to 73 years in the United Kingdom between 2006 and 2010. PRSs were...

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Identifiers

PMID: 40113122
DOI: 10.1016/j.biopsych.2025.03.006
PMCID: PMC12353670

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