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Article

Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study.

The Lancet. Microbe - 1 May 2025

Meier-Scherling Cecile P G, Watson Oliver J, Asua Victor, Ghinai Isaac, Katairo Thomas, Garg Shreeya, Conrad Melissa D, Rosenthal Philip J, Okell Lucy C, Bailey Jeffrey A

Abstract excerpt

BACKGROUND: Artemisinin partial resistance, mediated by mutations in the Plasmodium falciparum kelch13 gene (k13), rapidly spread in southeast Asia, undermining the antimalarial effectiveness of artemisinin-based combination therapies. k13 mutations have also arisen in Africa, but their rates of increase are not well characterised. We aimed to quantify the selection of k13 mutations in Africa and compare the...

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Identifiers

PMID: 40112841
DOI: 10.1016/j.lanmic.2024.101027
PMCID: PMC12128186

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