Article
Spatial and molecular mapping of Pfkelch13 gene polymorphism in Africa in the era of emerging Plasmodium falciparum resistance to artemisinin: a systematic review.
The Lancet. Infectious diseases - 1 Apr 2021
Kayiba Nadine K, Yobi Doudou M, Tshibangu-Kabamba Evariste, Tuan Vo P, Yamaoka Yoshio, Devleesschauwer Brecht, Mvumbi Dieudonné M, Okitolonda Wemakoy Emile, De Mol Patrick, Mvumbi Georges L, Hayette Marie-Pierre, Rosas-Aguirre Angel, Speybroeck Niko
Abstract excerpt
The spread of Plasmodium falciparum isolates carrying mutations in the kelch13 (Pfkelch13) gene associated with artemisinin resistance (PfART-R) in southeast Asia threatens malaria control and elimination efforts. Emergence of PfART-R in Africa would result in a major public health problem. In this systematic review, we investigate the frequency and spatial distribution of Pfkelch13 mutants in Africa, including...
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