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Article

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda.

Nature medicine - 1 Sept 2026

Niaré Karamoko, Tafesse Bersabeh, Treat Mayland, Sadler Jacob M, Okitwi Martin, Orena Stephen, Asua Victor, Kreutzfeld Oriana, Legac Jenny, Marglous Jacob, Nsobya Samuel L, Yeka Adoke, Richard Dave, Ferdig Michael T, Mukherjee Angana, Rosenthal Philip J, Juliano Jonathan J, Bailey Jeffrey A, Conrad Melissa D

Abstract excerpt

Artemisinin-based combination therapies are the cornerstone of malaria treatment and control. In Africa, artemether-lumefantrine is the most widely used first-line artemisinin-based combination therapy, but its efficacy in Uganda is increasingly threatened by the emergence of artemisinin partial resistance and reduced lumefantrine susceptibility. To identify loci contributing to this decreased susceptibility,...

Read the complete abstract on PubMed

Topics

Plasmodium falciparum
Uganda
Humans
Antimalarials
Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Malaria, Falciparum

Haplotypes

Polymorphism, Genetic

Artemisinins

Protozoan Proteins

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42608602
DOI: 10.1038/s41591-026-04590-5
PMCID: PMC13577890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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