Article
Absence of in vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.
Malaria journal - 9 Jan 2017
Balikagala Betty, Mita Toshihiro, Ikeda Mie, Sakurai Miki, Yatsushiro Shouki, Takahashi Nobuyuki, Tachibana Shin-Ichiro, Auma Mary, Ntege Edward H, Ito Daisuke, Takashima Eizo, Palacpac Nirianne Marie Q, Egwang Thomas G, Onen Joseph Okello, Kataoka Masatoshi, Kimura Eisaku, Horii Toshihiro, Tsuboi Takafumi
Abstract excerpt
BACKGROUND: Individual drug treatment may select resistant parasites in the human body, a process termed in vivo selection. Some single nucleotide polymorphisms in Plasmodium falciparum chloroquine-resistance transporter (pfcrt) and multidrug resistance gene 1 (pfmdr1) genes have been reportedly selected after artemether-lumefantrine treatment. However, there is a paucity of data regarding in vivo selection of P....
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