Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda.

doi:10.1128/aac.01659-23

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Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda.

Antimicrobial agents and chemotherapy - 7 Aug 2024

Awor Phyllis, Coppée Romain, Khim Nimol, Rondepierre Laurine, Roesch Camille, Khean Chanra, Kul Chanvong, Eam Rotha, Lorn Thornleaksmey, Athieno Proscovia, Kimera Joseph, Balikagala Betty, Odongo-Aginya Emmanuel I, Anywar Denis A, Mita Toshihiro, Clain Jérôme, Ringwald Pascal, Signorell Aita, Lengeler Christian, Burri Christian, Ariey Frédéric, Hetzel Manuel W, Witkowski Benoit

Abstract excerpt

Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for uncomplicated malaria in Africa almost two decades ago. Recent studies in East Africa have reported a gradual increase in kelch13 (k13) mutant parasites associated with reduced artesunate efficacy. As part of the Community Access to Rectal Artesunate for Malaria project, we collected blood samples from 697 children with...

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PMID: 39028193
DOI: 10.1128/aac.01659-23
PMCID: PMC11304714

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