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Article

The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda.

Antimicrobial agents and chemotherapy - 1 Oct 2019

Conrad Melissa D, Nsobya Sam L, Rosenthal Philip J

Abstract excerpt

Artemisinin-based combination therapies (ACTs) are the standard of care to treat uncomplicated falciparum malaria. However, resistance to artemisinins, defined as delayed parasite clearance after therapy, has emerged in Southeast Asia, and the spread of resistance to sub-Saharan Africa could have devastating consequences. Artemisinin resistance has been associated in Southeast Asia with multiple nonsynonymous...

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Identifiers

PMID: 31358588
DOI: 10.1128/AAC.01234-19
PMCID: PMC6761569

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