Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mediterranean vs. Western diet effects on the primate cerebral cortical pre-synaptic proteome: Relationships with the transcriptome and multi-system phenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2025

Berson Eloise, Frye Brett M, Gajera Chandresh R, Saarunya Geetha, Perna Amalia, Phongpreecha Thanaphong, Shome Sayane, Negrey Jacob D, Aghaeepour Nima, Montine Thomas J, Craft Suzanne, Register Thomas C, Shively Carol A

Abstract excerpt

INTRODUCTION: Diet quality mediates aging-related risks of cognitive decline, neurodegeneration, and Alzheimer's disease (AD) through poorly defined mechanisms. METHODS: The effects of diet on the presynaptic proteome of the temporal cortex were assessed in 36 female cynomolgus macaques randomized to Mediterranean or Western diets for 31 months. Associations between the presynaptic proteome, determined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Cortex
Share to Diet, Mediterranean

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diet, Western

Share to Macaca fascicularis

Share to Presynaptic Terminals

Share to Proteome

Share to Temporal Lobe

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 40109017
DOI: 10.1002/alz.70041
PMCID: PMC11923382

Genes

SLC6A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediterranean vs. Western diet effects on the primate cerebral cortical pre-synaptic proteome: Relationships with the transcriptome and multi-system phenotypes.PMID 40109017Read ↗

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotypeSemantic proximity Read ↗

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotypeSemantic proximity Read ↗

An atlas of protein-protein associations of human tissues prioritizes candidate disease genesSemantic proximity Read ↗

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.Semantic proximity Read ↗

Obesity-related brain atrophy is independent of Alzheimer’s disease protein pathwaysSemantic proximity Read ↗

Joint multi-omics profiling of brain and body health in agingSemantic proximity Read ↗

A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain SamplesSemantic proximity Read ↗

Diet, psychosocial stress, and Alzheimer’s disease-related neuroanatomy in female nonhuman primatesSemantic proximity Read ↗

A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbiditySemantic proximity Read ↗

Proteomic signatures of cognitive resilience in LOU/c/Jall rats converge with inverse hippocampal axes of Alzheimer’s diseaseSemantic proximity Read ↗

Hyperspherical geometry positions the lipidome as a partly independent axis of human brain organizationSemantic proximity Read ↗

Adipose tissue coregulates cognitive functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.