Article
Hyperspherical geometry positions the lipidome as a partly independent axis of human brain organization
2025-09-19
Abstract excerpt
The brain’s transcriptome is well mapped, but the spatial organization of lipids—over half of brain dry mass—remains poorly defined. We profiled lipidomic (419 species) and transcriptomic (15,013 genes) signatures from 35 anatomically defined regions in four healthy adult donors, measured from the same tissue samples. Both modalities recapitulate major neuroanatomical divisions, yet the lipidome shows distinctive...
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Identifiers and source
- Literature Corpus work
- 374d68d6-ab19-582c-a85e-f6a2c0ae7024
- DOI
- 10.1101/2025.09.18.677162