Article
A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbidity
2020-10-27
Abstract excerpt
Synapses contain highly complex proteomes which control synaptic transmission, cognition and behaviour. Genes encoding synaptic proteins are associated with neuronal disorders many of which show clinical co-morbidity. Our hypothesis is that there is mechanistic overlap that is emergent from the network properties of the molecular complex. To test this requires a detailed and comprehensive molecular network model....
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- c701b30c-1d17-5607-8a60-357bcc8707b0
- DOI
- 10.1101/2020.10.27.356899