Back to search

Article

A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain Samples

2025-06-08

Abstract excerpt

Recent advancements in neuroproteomics have enabled detailed analysis of protein expression and function in the human brain. Post-mortem human brain studies have significantly advanced our understanding of the relationship between genetics, cell biology of neurological and psychiatric disorders and their clinical diagnosis. Synaptic dysfunction often has a central role in these disorders. Therefore, we specificall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
55f01298-e36f-50d2-becd-7d9630f10240
DOI
10.1101/2025.06.04.657790
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain SamplesDOI 10.1101/2025.06.04.657790
Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexesSemantic proximity
Molecularly-guided spatial proteomics captures single-cell identity of the healthy and diseased nervous systemSemantic proximity
Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotypeSemantic proximity
Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotypeSemantic proximity
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortexSemantic proximity
Synaptic proteomics reveal distinct molecular signatures of cognitive change and<i>C9ORF72</i>repeat expansion in the human ALS cortexSemantic proximity
Whole-Cell Dissociated Suspension Analysis in Human Brain Neurodegenerative Disease: A Pilot StudySemantic proximity
Synaptic Proteome Alterations in the Primary Auditory Cortex of SchizophreniaSemantic proximity
Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory NeuronsSemantic proximity
Proteomics of brain synapses and molecular dissection of synaptic subdomains.Semantic proximity
Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in <i>C9ORF72</i> -Frontotemporal DementiaSemantic proximity
Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.