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Article

Osteosarcoma Exosome Priming of Primary Human Lung Fibroblasts Induces an Immune Modulatory and Protumorigenic Phenotype.

Cancer research communications - 1 Apr 2025

Palmer Eric P, Cronise Kathryn E, Haines Laurel A, Das Sunetra, Offermann Aaron, Easton Carina P, Regan Daniel P

Abstract excerpt

ABSTRACT: Osteosarcoma (OS) is the most common malignant bone cancer. Thirty to forty percent of all patients with OS develop tumor recurrence, almost exclusively in the form of lung metastasis, which is associated with a dismal 20% 5-year survival rate. Cancer-associated fibroblasts are a critical cell type within the lung tumor microenvironment that promote immune suppression, drug resistance, and tumor cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40099972
DOI: 10.1158/2767-9764.CRC-24-0371
PMCID: PMC11987067

Genes

CCL2
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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