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Article

Modulating tumoral exosomes and fibroblast phenotype using nanoliposomes augments cancer immunotherapy.

Science advances - 1 Mar 2024

Freag May S, Mohammed Mostafa T, Kulkarni Arpita, Emam Hagar E, Maremanda Krishna P, Elzoghby Ahmed O

Abstract excerpt

Cancer cells program fibroblasts into cancer associated fibroblasts (CAFs) in a two-step manner. First, cancer cells secrete exosomes to program quiescent fibroblasts into activated CAFs. Second, cancer cells maintain the CAF phenotype via activation of signal transduction pathways. We rationalized that inhibiting this two-step process can normalize CAFs into quiescent fibroblasts and augment the efficacy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38416824
DOI: 10.1126/sciadv.adk3074
PMCID: PMC10901379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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