Article
Lung CSC-derived exosomal miR-210-3p contributes to a pro-metastatic phenotype in lung cancer by targeting FGFRL1.
Journal of cellular and molecular medicine - 1 Jun 2020
Wang Li, He Jun, Hu Haoyue, Tu Li, Sun Zhen, Liu Yanyang, Luo Feng
Abstract excerpt
Lung cancer has the highest mortality rate among human cancers, and the majority of deaths can be attributed to metastatic spread. Lung cancer stem cells (CSCs) are a component of the tumour microenvironment that contributes to this process. Exosomes are small membrane vesicles secreted by all types of cells that mediate cell interactions, including cancer metastasis. Here, we show that lung CSC-derived exosomes...
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