Article
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Clinical and translational medicine - 1 Nov 2022
Zhang Zhichang, Ji Weiping, Huang Jin, Zhang Yawen, Zhou Yan, Zhang Jianjun, Dong Yang, Yuan Ting, Yang Qingcheng, Ding Xiaomin, Tang Lina, Li Hongtao, Yin Junyi, Wang Yonggang, Ji Tong, Fei Jia, Zhang Bing, Chen Peizhan, Hu Haiyan
Abstract excerpt
PURPOSE: Malignant pleural effusion (MPE) is an adverse prognostic factor in patients with osteoblastic osteosarcoma; however, the cellular contexts of MPE are largely unknown. EXPERIMENTAL DESIGN: We performed single-cell RNA-sequencing (scRNA-seq) on 27 260 cells from seven MPE samples and 91 186 cells from eight osteosarcoma tissues, including one recurrent, one lung metastasis and six primary tumour (PT)...
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