Article

Osteosarcoma cells relate functionally with stromal cells favoring a lung niche permissive for the establishment of metastatic tumor cells

2023-10-24

Abstract excerpt

Osteosarcoma (OS) is the most common bone tumor and 20% of the patients are diagnosed with metastatic OS at first diagnosis. Undetectable metastases at the time of diagnosis are also a major complication. MSCs display abilities that enable tumor growth. We demonstrated that in vitro, MSCs migrated more towards the secretome of non-metastatic OS cells. When challenged to a secretome from lungs pre-loaded with OS ce...

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Literature Corpus work: 14f31e29-8db9-5a5c-94c3-1066a83623f5
DOI: 10.21203/rs.3.rs-3471838/v1

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