Article
M2 macrophage-derived exosomal EHF transcriptionally activates FGFR1 to promote malignant phenotypes and glycolysis in NSCLC.
Journal of bioenergetics and biomembranes - 11 Aug 2026
Zhang Dan, Wu Wei, Ge Peng, Cao Xia, Qin Yuan, Dong Danfeng, Yang Jin
Abstract excerpt
BACKGROUND: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, largely due to the supportive role of the tumor microenvironment (TME). Tumor-associated macrophages, particularly the M2 phenotype, are pivotal in promoting NSCLC progression. Exosomes, key mediators of intercellular communication, can transfer functional cargo from M2 macrophages to cancer cells,...
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