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Article

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway.

Journal of hematology & oncology - 18 Apr 2016

Li Xiaoxia, Wang Shihua, Zhu Rongjia, Li Hongling, Han Qin, Zhao Robert Chunhua

Abstract excerpt

BACKGROUND: In tumor microenvironment, a continuous cross-talk between cancer cells and other cellular components is required to sustain tumor progression. Accumulating evidence suggests that exosomes, a novel way of cell communication, play an important role in such cross-talk. Exosomes could facilitate the direct intercellular transfer of proteins, lipids, and miRNA/mRNA/DNAs between cells. Since mesenchymal...

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Share to Antibodies, Neutralizing
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-8

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Share to Microscopy, Electron, Transmission

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Source

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Identifiers

PMID: 27090786
DOI: 10.1186/s13045-016-0269-y
PMCID: PMC4836087

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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