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Article

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

13 Mar 2019

Abstract excerpt

BACKGROUND: Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypoxia affects both cancer and stromal cells. Exosomes are recognized as mediators of intercellular communication. Here, we aim to further elucidate the communication between BMSC-derived exosomes...

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Share to Extracellular vesicles in disease
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30866952
DOI: 10.1186/s12943-019-0959-5

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