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Article

Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools.

Emerging microbes & infections - 1 Dec 2025

Zhang Xiao, Di Yuchang, Zhang Yu, Hu Youwei, Chi Mingzhe, Kang Jian, Zheng Yuqing, Wang Hengyu, Wang Yu, Chen Jiazhen, Zhang Xuelian

Abstract excerpt

Ribonucleotide reductase (RNR) catalyzes the synthesis of four deoxyribonucleoside triphosphates (dNTPs), which are essential for DNA replication. Although dNTP imbalances reduce replication fidelity and elevate mutation rates, the impact of RNR dysfunction on Mycobacterium tuberculosis (Mtb) physiology and drug resistance remains unknown. Here, we constructed inducible knockdown strains for the RNR R1 subunit...

Read the complete abstract on PubMed

Topics

Mycobacterium smegmatis
Ribonucleotide Reductases
Homeostasis
Bacterial Proteins
Mycobacterium tuberculosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Deoxyribonucleotides

Mutation

Drug Resistance, Bacterial

Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 40099407
DOI: 10.1080/22221751.2025.2480698
PMCID: PMC11948356

Genes

NDP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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