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Article

The contribution of Nth and Nei DNA glycosylases to mutagenesis in Mycobacterium smegmatis.

DNA repair - 1 Jan 2014

Moolla Nabiela, Goosens Vivianne J, Kana Bavesh D, Gordhan Bhavna G

Abstract excerpt

The increased prevalence of drug resistant strains of Mycobacterium tuberculosis (Mtb) indicates that significant mutagenesis occurs during tuberculosis disease in humans. DNA damage by host-derived reactive oxygen/nitrogen species is hypothesized to be critical for the mutagenic process in Mtb thus, highlighting an important role for DNA repair enzymes in maintenance of genome fidelity. Formamidopyrimidine...

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PMID: 24342191
DOI: 10.1016/j.dnarep.2013.11.003

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