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Role of the DinB Homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis

6 Feb 2010

Abstract excerpt

The environment encountered by Mycobacterium tuberculosis during infection is genotoxic. Most bacteria tolerate DNA damage by engaging specialized DNA polymerases that catalyze translesion synthesis (TLS) across sites of damage. M. tuberculosis possesses two putative members of the DinB class of Y-family DNA polymerases, DinB1 (Rv1537) and DinB2 (Rv3056); however, their role in damage tolerance, mutagenesis, and...

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PMID: 20139184
DOI: 10.1128/jb.01135-09

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