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Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis

6 Feb 2020

Abstract excerpt

Menaquinone (vitamin K 2 ) plays a vital role in energy generation and environmental adaptation in many bacteria, including the human pathogen Mycobacterium tuberculosis ( Mtb ). Although menaquinone levels are known to be tightly linked to the cellular redox/energy status of the cell, the regulatory mechanisms underpinning this phenomenon are unclear. The first committed step in menaquinone biosynthesis is...

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PMID: 32029475
DOI: 10.1074/jbc.ra119.012158

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