Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Function and Regulation of Class I Ribonucleotide Reductase-Encoding Genes in Mycobacteria

22 Nov 2008

Abstract excerpt

Ribonucleotide reductases (RNRs) are crucial to all living cells, since they provide deoxyribonucleotides (dNTPs) for DNA synthesis and repair. In Mycobacterium tuberculosis, a class Ib RNR comprising nrdE- and nrdF2-encoded subunits is essential for growth in vitro. Interestingly, the genome of this obligate human pathogen also contains the nrdF1 (Rv1981c) and nrdB (Rv0233) genes, encoding an alternate class Ib...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antimicrobial Resistance in Staphylococcus
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19028890
DOI: 10.1128/jb.01409-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Function and Regulation of Class I Ribonucleotide Reductase-Encoding Genes in MycobacteriaPMID 19028890Read ↗

Role of the DinB Homologs Rv1537 and Rv3056 in Mycobacterium tuberculosisSemantic proximity Read ↗

Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis.Semantic proximity Read ↗

The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis.Semantic proximity Read ↗

Domains within RbpA Serve Specific Functional Roles That Regulate the Expression of Distinct Mycobacterial Gene SubsetsSemantic proximity Read ↗

Rv3722c governs aspartate-dependent nitrogen metabolism in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.Semantic proximity Read ↗

Metal-independent ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogensSemantic proximity Read ↗

Prominent transcriptomic changes in Mycobacterium intracellulare under acidic and oxidative stressSemantic proximity Read ↗

DNA repair systems and the pathogenesis of <i>Mycobacterium tuberculosis</i>: varying activities at different stages of infectionSemantic proximity Read ↗

Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro.Semantic proximity Read ↗

Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases.Semantic proximity Read ↗

Rv0687 a Putative Short-Chain Dehydrogenase is indispensable for pathogenesis of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.