Article
Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.
The international journal of neuropsychopharmacology - 23 Jul 2021
Ohi Kazutaka, Nishizawa Daisuke, Sugiyama Shunsuke, Takai Kentaro, Kuramitsu Ayumi, Hasegawa Junko, Soda Midori, Kitaichi Kiyoyuki, Hashimoto Ryota, Ikeda Kazutaka, Shioiri Toshiki
Abstract excerpt
BACKGROUND: Impairments in intelligence are more severe in patients with schizophrenia (SCZ) than in patients with bipolar disorder (BD) despite clinical and genetic similarities between the disorders. Genetic loci differentiating SCZ from BD, that is, SCZ-specific risk, have been identified. Polygenetic [risk] scores (PGSs) for SCZ-specific risk are higher in SCZ patients than in healthy controls (HCs). However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.