Article
The strength of organ, tissue, and body field effects determines the frequency of all neoplasia.
Annals of the New York Academy of Sciences - 1 Apr 2025
de Groen Piet C
Abstract excerpt
In 1953, Danely Slaughter proposed the concept of field cancerization, or field effect, to explain the development of additional neoplasia of similar type. A recent theory (de Groen, 2022) states that all DNA is exposed to a constant source of damage, resulting in a constant rate of germline and somatic DNA mutations. If the field effect and constant mutation theories are correct and a single somatic mutation...
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