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Article

Somatic mutation theory of carcinogenesis: why it should be dropped and replaced.

Molecular carcinogenesis - 1 Dec 2000

Sonnenschein C, Soto A M

Abstract excerpt

The somatic mutation theory of carcinogenesis has been the dominant force driving cancer research during the 20th century. In brief, it proposes that successive DNA mutations in a single cell cause cancer (monoclonality). This theory places carcinogenesis at the cellular and subcellular hierarchical levels of biological complexity. Its basic premises are that (1) cancer is a defect of the control of cell...

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PMID: 11170258
DOI: 10.1002/1098-2744(200012)29:4<205::aid-mc1002>3.0.co;2-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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