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Article

Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma.

Environmental research - 1 Aug 2023

Moolgavkar Suresh, Chang Ellen T, Luebeck E Georg

Abstract excerpt

The current paradigm of carcinogenesis as a cellular evolutionary process driven by mutations of a few critical driver genes has immediate logical implications for the epidemiology of cancer. These include the impact of age on cancer risk, the role played by inherited tumor predisposition syndromes, and the interaction of genetics and environmental exposures on cancer risk. In this paper, we explore the following...

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Identifiers

PMID: 36965799
DOI: 10.1016/j.envres.2022.114582

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