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Article

The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 2011

Soto Ana M, Sonnenschein Carlos

Abstract excerpt

The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by...

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PMID: 21503935
DOI: 10.1002/bies.201100025
PMCID: PMC3933226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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