Article
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein.
Molecular biology of the cell - 1 Mar 2021
Nouri-Nejad Daniel, O'Donnell Brooke L, Patil Chetan S, Sanchez-Pupo Rafael E, Johnston Danielle, Sayedyahossein Samar, Jurcic Kristina, Lau Rebecca, Gyenis Laszlo, Litchfield David W, Jackson Michael F, Gloor Gregory B, Penuela Silvia
Abstract excerpt
Pannexin 1 (PANX1) is a glycoprotein that forms large pore channels capable of passing ions and metabolites such as ATP for cellular communication. PANX1 has been implicated in many diseases including breast cancer and melanoma, where inhibition or deletion of PANX1 reduced the tumorigenic and metastatic properties of the cancer cells. We interrogated the effect of single amino acid changes in various PANX1...
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