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Article

Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.

Biochemical and biophysical research communications - 9 Apr 2021

Purohit Rutambhara, Bera Amal Kanti

Abstract excerpt

Pannexin 1 (Panx1) has been implicated in a plethora of physiological and pathophysiological processes. It is one of the major ATP release channels in many cell types. Extracellular ATP, activates purinergic P2X and P2Y receptors, triggering several signaling cascades. A disease-associated mutation, Arg-217-His (R217H) in the 3rd transmembrane domain of Panx1 attenuates channel functions through an unknown...

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PMID: 33640607
DOI: 10.1016/j.bbrc.2021.02.060

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