Article
Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis.
Nature communications - 13 Mar 2025
Blazickova Jitka, Trivedi Shalini, Bowman Richard, Sivakumar Geetha Sowmya, Subah Silma, Scuzzarella Michelle, Chang Alexander, Chandran Uma R, Yanowitz Judith L, Smolikove Sarit, Jantsch Verena, Zetka Monique, Silva Nicola
Abstract excerpt
Faithful meiotic segregation requires pairwise alignment of the homologous chromosomes and their synaptonemal complex (SC) mediated stabilization. Here, we investigate factors that promote and coordinate these events during C. elegans meiosis. We identify BRA-2 (BMP Receptor Associated family member 2) as an interactor of HIM-17, previously shown to promote double-strand break formation. We found that loss of...
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