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Article

HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

PLoS genetics - 1 Jan 2012

Zhang Weibin, Miley Natasha, Zastrow Michael S, MacQueen Amy J, Sato Aya, Nabeshima Kentaro, Martinez-Perez Enrique, Mlynarczyk-Evans Susanna, Carlton Peter M, Villeneuve Anne M

Abstract excerpt

During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be tightly coordinated. We identify HAL-2 as a key mediator in this coordination, showing that HAL-2 promotes pairing largely by preventing detrimental effects of SC...

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Identifiers

PMID: 22912597
DOI: 10.1371/journal.pgen.1002880
PMCID: PMC3415444

Genes

HAL
SYP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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