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Article

HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis.

Cell - 16 Dec 2005

Phillips Carolyn M, Wong Chihunt, Bhalla Needhi, Carlton Peter M, Weiser Pinky, Meneely Philip M, Dernburg Abby F

Abstract excerpt

The him-8 gene is essential for proper meiotic segregation of the X chromosomes in C. elegans. Here we show that loss of him-8 function causes profound X chromosome-specific defects in homolog pairing and synapsis. him-8 encodes a C2H2 zinc-finger protein that is expressed during meiosis and concentrates at a site on the X chromosome known as the meiotic pairing center (PC). A role for HIM-8 in PC function is...

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Identifiers

PMID: 16360035
DOI: 10.1016/j.cell.2005.09.035
PMCID: PMC4435792

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Source receipt: pubmed, retrieved 7 Sept 2026.

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HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis.PMID 16360035Read ↗

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