Article
A quality control mechanism coordinates meiotic prophase events to promote crossover assurance.
PLoS genetics - 1 Apr 2014
Deshong Alison J, Ye Alice L, Lamelza Piero, Bhalla Needhi
Abstract excerpt
Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated to promote the obligate crossover is not well understood. PCH-2 is a highly conserved meiotic AAA+-ATPase that has been assigned a variety of functions; whether...
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