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Article

C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination.

Cell - 20 Aug 2004

Reddy Kirthi C, Villeneuve Anne M

Abstract excerpt

Initiation of meiotic recombination by double-strand breaks (DSBs) must occur in a controlled fashion to avoid jeopardizing genome integrity. Here, we identify chromatin-associated protein HIM-17 as a link between chromatin state and DSB formation during C. elegans meiosis. Dependencies of several meiotic prophase events on HIM-17 parallel those seen for DSB-generating enzyme SPO-11: HIM-17 is essential for DSB...

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Identifiers

PMID: 15315757
DOI: 10.1016/j.cell.2004.07.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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