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Article

Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysis.

Journal of the American Heart Association - 18 Mar 2025

Liu Yi, Shen Chenfu, Cao Yu

Abstract excerpt

BACKGROUND: Observational studies have shown a significant association between immune cells and heart failure (HF). Nevertheless, the precise biological mechanisms underlying this association remain unclear. METHODS: To investigate the causative relationships and underlying mechanisms between immune cell traits and adult HF, 3 main methods of Mendelian randomization were used: 2-sample Mendelian randomization,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40079309
DOI: 10.1161/JAHA.124.037265
PMCID: PMC12132714

Genes

CD33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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