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Article

Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 7 Jan 2025

Liu Yi, Cao Yu

Abstract excerpt

BACKGROUND: A significant association between immune cells and sepsis has been suggested by observational studies. However, the precise biological mechanisms underlying this association remain unclear. Therefore, we employed a Mendelian randomization (MR) approach to investigate the causal relationship between immune cells and genetic susceptibility to sepsis, and to explore the potential mediating role of blood...

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Dendritic Cells
E-Selectin
Genome-Wide Association Study
L-Selectin
Mediation Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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PMID: 39762630
DOI: 10.1007/s00011-024-01971-9

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