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Article

Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study.

Frontiers in immunology - 1 Jan 2024

Cao Zhenghua, Wu Tong, Fang Yakun, Sun Feng, Ding Huan, Zhao Lingling, Shi Li

Abstract excerpt

Objective: This study employed Mendelian Randomization (MR) to investigate the causal relationships among immune cells, COPD, and potential metabolic mediators. Methods: Utilizing summary data from genome-wide association studies, we analyzed 731 immune cell phenotypes, 1,400 plasma metabolites, and COPD. Bidirectional MR analysis was conducted to explore the causal links between immune cells and COPD,...

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Source

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Identifiers

PMID: 38868780
DOI: 10.3389/fimmu.2024.1406234
PMCID: PMC11168115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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