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Article

Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization.

Scientific reports - 23 Aug 2024

Chen Jiangwei, Yu Haichun, Liu Huihua, Yu Han, Liang Shuang, Wu Qiong, Zhang Xian, Zeng Rong, Diao Limei

Abstract excerpt

Our study investigated the causal relationship between immune cells, metabolites, and epilepsy using two-sample Mendelian Randomization (MR) and mediation MR analysis of 731 immune cell traits and 1400 metabolites. Our core methodology centered on inverse-variance weighted MR, supplemented by other methods. This approach was crucial in clarifying the potential intermediary functions of metabolites in the genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39179617
DOI: 10.1038/s41598-024-70370-1
PMCID: PMC11343848

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