Article
Clonal hematopoiesis landscape in frequent blood donors.
Blood - 22 May 2025
Karpova Darja, Huerga Encabo Hector, Donato Elisa, Calderazzo Silvia, Scherer Michael, Llorian-Sopena Miriam, Leppä Aino-Maija, Würth Roberto, Stelmach Patrick, Papazoglou Despoina, Ferrelli Alessandra, Ngo Steven, Kotova Iuliia, Harenkamp Sabine, Zimmer Kai, Wolf Dominik, Panten Jasper, Reed John, Przybylla Adriana, Tonn Torsten, Kopp-Schneider Annette, Velten Lars, DiPersio John F, Wong Terrence N, Bonnet Dominique, Bonig Halvard, Trumpp Andreas
Abstract excerpt
ABSTRACT: Donor blood saves lives, yet the potential impact of recurrent large-volume phlebotomy on donor health and hematopoietic stem cells (HSCs) remains largely unexplored. In our study, we conducted a comprehensive screening of 217 older male volunteer donors with a history of extensive blood donation (>100 lifetime donations) to investigate the phenomenon of clonal hematopoiesis (CH). No significant...
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