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Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

15 Nov 2021

Abstract excerpt

Abstract To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord blood samples, with CRISPR/Cas9 technology. Site-specific mutations were introduced in defined regions of DNMT3A , TET2 , and ASXL1 in CD34 + progenitor cells...

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PMID: 34782715
DOI: 10.1038/s41375-021-01469-x

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