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Article

Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2022

Gibson Christopher J, Kim Haesook T, Zhao Lin, Murdock H Moses, Hambley Bryan, Ogata Alana, Madero-Marroquin Rafael, Wang Shiyu, Green Lisa, Fleharty Mark, Dougan Tyler, Cheng Chi-An, Blumenstiel Brendan, Cibulskis Carrie, Tsuji Junko, Duran Madeleine, Gocke Christopher D, Antin Joseph H, Nikiforow Sarah, DeZern Amy E, Chen Yi-Bin, Ho Vincent T, Jones Richard J, Lennon Niall J, Walt David R, Ritz Jerome, Soiffer Robert J, Gondek Lukasz P, Lindsley R Coleman

Abstract excerpt

PURPOSE: Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune function is uncertain. PATIENTS AND METHODS: We performed targeted error-corrected sequencing on samples from 1,727 donors age 40 years or older and assessed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34793200
DOI: 10.1200/JCO.21.02286
PMCID: PMC8718176

Genes

DNMT3A
TET2
DDX41
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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