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Article

Dissecting genetic regulation of metabolic coordination.

Briefings in bioinformatics - 4 Mar 2025

Hector Emily C, Zhang Daiwei, Tian Leqi, Feng Junning, Yin Xianyong, Xu Tianyi, Laakso Markku, Bai Yun, Xiao Jiashun, Kang Jian, Yu Tianwei

Abstract excerpt

Understanding genetic regulation of metabolism is critical for gaining insights into the causes of metabolic diseases. Traditional metabolome-based genome-wide association studies (mGWAS) focus on static associations between single nucleotide polymorphisms (SNPs) and metabolite levels, overlooking the changing relationships caused by genotypes within the metabolic network. Notably, some metabolites exhibit...

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PMID: 40067114
DOI: 10.1093/bib/bbaf095
PMCID: PMC11894804

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