Article

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

2022-04-04

Abstract excerpt

<h4>Summary</h4> Pleiotropy and genetic correlation are widespread features in GWAS, but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino acid catabolism, glycolysis, and ketone body metabolism in a subset of UK Biobank. We utilize the well-documented biochemistry jointly impacting these metabolites to analyze pleiotropic...

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Literature Corpus work: 59c921c9-ad50-5cf0-935a-d6e48c60151a
DOI: 10.1101/2022.04.02.486791

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