Article
Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.
eLife - 8 Sept 2022
Smith Courtney J, Sinnott-Armstrong Nasa, Cichońska Anna, Julkunen Heli, Fauman Eric B, Würtz Peter, Pritchard Jonathan K
Abstract excerpt
Pleiotropy and genetic correlation are widespread features in genome-wide association studies (GWAS), but they are often difficult to interpret at the molecular level. Here, we perform GWAS of 16 metabolites clustered at the intersection of amino acid catabolism, glycolysis, and ketone body metabolism in a subset of UK Biobank. We utilize the well-documented biochemistry jointly impacting these metabolites to...
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